The Department of Homeland Security (DHS) Science and Technology Directorate (S&T) is conducting ongoing research that will help scientists better understand the coronavirus that causes the disease known as COVID-19, and methods to prevent its spread. In the Trump Administration’s whole of government effort, this work is being done at the National Biodefense Analysis and Countermeasures Center (NBACC) laboratory in cooperation with the DHS Countering Weapons of Mass Destruction Office. As results become available, NBACC will provide updates on their findings to DHS and response agencies, especially those that may immediately impact efforts to mitigate transmission.